What To Pair With Wellbutrin For Anxiety in 2024

If you’re someone who struggles with anxiety and has been prescribed Wellbutrin, you may be wondering what other medications or therapies can complement its effects. Dealing with anxiety can be challenging, but finding the right combination of treatments can make a significant difference in managing your symptoms. In this article “What To Pair With Wellbutrin For Anxiety”, we’ll explore different options that you can pair with Wellbutrin to help alleviate anxiety and enhance your mental well-being. So, let’s dive into some potential solutions and discover the possibilities that lie ahead!

Psychotherapy Options

Cognitive Behavioral Therapy (CBT)

Cognitive Behavioral Therapy (CBT) is a widely recognized and highly effective form of talk therapy that can be a valuable option for individuals experiencing anxiety. CBT focuses on identifying and challenging negative thought patterns and behaviors that contribute to anxiety. Through this therapy, you will learn techniques to reframe your thinking and develop healthier coping strategies. CBT is often a short-term, goal-oriented therapy that empowers you to take an active role in managing your anxiety.

Exposure Therapy

Exposure Therapy is a type of psychotherapy that aims to reduce anxiety and fear by gradually exposing you to the situations or objects that trigger your anxiety. This therapeutic approach helps you confront your fears in a safe and controlled manner, allowing you to build resilience and confidence. Over time, exposure therapy can help you develop new, more adaptive responses to anxiety triggers, leading to a decrease in overall anxiety levels.

Dialectical Behavior Therapy (DBT)

Dialectical Behavior Therapy (DBT) is a highly effective therapy that combines elements of cognitive-behavioral techniques with mindfulness and acceptance strategies. It was initially developed to treat borderline personality disorder but has also been found to be beneficial for individuals struggling with anxiety. DBT focuses on enhancing emotional regulation, distress tolerance, interpersonal effectiveness, and mindfulness. By learning and practicing these skills, you can better manage anxiety symptoms and improve your overall well-being.

Interpersonal Therapy (IPT)

Interpersonal Therapy (IPT) is a therapy focused on improving interpersonal functioning and managing emotional difficulties. By exploring your relationships and communication patterns, IPT can help you address interpersonal conflicts and improve your social support system. This therapy can be particularly helpful if your anxiety is rooted in relationship issues or significant life changes. Through IPT, you can develop healthier coping strategies and improve your ability to handle anxiety-inducing situations.

What To Pair With Wellbutrin For Anxiety

Other Medications

Selective Serotonin Reuptake Inhibitors (SSRIs)

Selective Serotonin Reuptake Inhibitors (SSRIs) are a commonly prescribed class of medications used for anxiety treatment. These medications work by increasing serotonin levels in the brain, which can help regulate mood and reduce anxiety symptoms. SSRIs generally require several weeks of consistent use before the therapeutic effects are fully realized. It’s essential to work closely with your healthcare provider to find the right SSRI and dosage that works best for you.


Benzodiazepines are medications that act as central nervous system depressants, providing short-term relief for anxiety symptoms. These medications work by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps calm the brain and nervous system. Benzodiazepines are typically prescribed for short periods due to their potential for dependence and abuse. It’s crucial to use benzodiazepines under the careful supervision of a healthcare provider.


Buspirone is an anti-anxiety medication that works differently from benzodiazepines and SSRIs. It acts on serotonin and dopamine receptors in the brain, helping to reduce anxiety symptoms. Buspirone is generally considered to have a lower risk of dependence and abuse compared to benzodiazepines. It may take a few weeks for buspirone to reach its full effect, and regular use is necessary for optimal results. Consult with your healthcare provider to determine if buspirone is a suitable option for your anxiety management.


Beta-blockers are medications primarily used to treat high blood pressure, but they can also be helpful in managing certain anxiety symptoms. Beta-blockers work by blocking the effects of adrenaline, which can reduce heart rate, blood pressure, and physical symptoms of anxiety, such as trembling and sweating. These medications are commonly used in specific situations, such as public speaking or performance anxiety, to help manage the physical manifestations of anxiety. It’s important to note that beta-blockers do not directly address the underlying psychological causes of anxiety.

What To Pair With Wellbutrin For Anxiety

Lifestyle Changes


Regular exercise has been shown to be an effective method for reducing anxiety symptoms. Physical activity helps release endorphins, which are natural mood-boosting chemicals in the brain. Engaging in activities such as jogging, swimming, or practicing yoga can help you manage stress, improve sleep quality, and increase overall well-being. Aim for at least 30 minutes of moderate exercise most days of the week to experience the benefits.

Meditation and Mindfulness

Meditation and mindfulness practices can be powerful tools in managing anxiety. By bringing your attention to the present moment without judgment, meditation and mindfulness can help calm an overactive mind and reduce anxious thoughts. There are various techniques you can explore, including focused breathing, guided imagery, or body scan meditations. Consistency is key, so aim to incorporate these practices into your daily routine for best results.

Dietary Modifications

Certain dietary modifications have been shown to have a positive impact on anxiety symptoms. Avoiding excessive caffeine and alcohol intake is crucial, as these substances can exacerbate anxiety. Instead, focus on incorporating foods rich in nutrients that support brain health, such as omega-3 fatty acids found in fatty fish, walnuts, and flaxseeds. Additionally, eating a well-balanced diet with plenty of fruits, vegetables, and whole grains can provide essential vitamins and minerals that support overall well-being.

Support Groups

Joining a support group can provide you with a safe space to share your experiences, learn from others, and gain valuable insights into managing anxiety. Support groups can be in-person or online and offer a sense of community and understanding. Hearing others’ stories and knowing that you are not alone in your struggles can be incredibly empowering and motivating. Reach out to local mental health organizations or search online directories to find a support group that suits your needs.

Natural Supplements

Omega-3 Fatty Acids

Omega-3 fatty acids, especially the types found in fish oil, have been studied for their potential benefits in reducing anxiety symptoms. These essential fatty acids play a crucial role in brain health and may help modulate neurotransmitters involved in anxiety regulation. While more research is needed, incorporating omega-3 fatty acids into your diet through supplements or foods like fish, chia seeds, and flaxseeds may have a positive impact on anxiety management.


Kava is a traditional herbal remedy that has been used for centuries for its calming and anxiety-reducing properties. The active compounds in kava are believed to affect neurotransmitters and promote relaxation. However, it’s important to note that kava may interact with certain medications and can have side effects when taken in large doses or for extended periods. Consult with your healthcare provider before incorporating kava into your anxiety management plan.


Passionflower has a long history of traditional use as an herbal remedy for anxiety. It contains compounds that have a calming effect on the nervous system, potentially reducing anxiety symptoms. Passionflower is commonly consumed as a tea or taken as a supplement. While generally considered safe, it may interact with specific medications, so it’s important to consult with your healthcare provider before adding passionflower to your regimen.

Valerian Root

Valerian root is another herbal option that has been used for centuries to promote relaxation and relieve anxiety. It is believed to enhance GABA activity in the brain, which helps regulate anxiety and promote sleep. Valerian root is commonly consumed in tea form or taken as a supplement. It’s essential to use valerian root cautiously and for short periods, as prolonged use may lead to side effects and possible interactions with certain medications.

Stress Reduction Techniques

Deep Breathing Exercises

Deep breathing exercises, also known as diaphragmatic breathing, can be a simple yet powerful technique to reduce anxiety. By taking slow, deep breaths from your diaphragm, you activate the body’s relaxation response, which helps counteract the symptoms of anxiety. Practice this technique whenever you feel anxious or incorporate it into daily relaxation exercises for maximum benefit.

Progressive Muscle Relaxation (PMR)

Progressive Muscle Relaxation (PMR) is a technique that involves systematically tensing and then releasing each muscle group in your body to promote relaxation. By progressively relaxing your muscles, you can alleviate physical tension and reduce overall anxiety levels. Guided PMR recordings or smartphone apps can guide you through the process, making it easier to learn and implement.

What To Pair With Wellbutrin For Anxiety

Yoga and Tai Chi

Yoga and Tai Chi are ancient practices that combine physical movement, breathing techniques, and mindfulness to promote overall well-being. Both practices have been shown to have significant benefits in reducing anxiety symptoms. Regular participation in yoga or Tai Chi classes can help improve flexibility, reduce muscle tension, and cultivate a sense of inner calm. Explore different styles and find an instructor who resonates with you to get the most out of these practices.


Aromatherapy involves the use of essential oils to promote relaxation and reduce anxiety. Scents like lavender, chamomile, and bergamot are known for their calming properties. You can inhale these oils directly, use them in a diffuser, or incorporate them into massage oils or bath products. Experiment with different scents to find what works best for you and always follow proper dilution guidelines.

Alternative Therapies


Acupuncture is an ancient Chinese healing practice that involves inserting thin needles into specific points on the body. It is believed to stimulate the body’s energy flow and promote balance. While research on acupuncture for anxiety is still limited, some studies suggest that it may help reduce anxiety symptoms. If considering acupuncture, ensure that you seek a qualified and reputable practitioner.

Massage Therapy

Massage therapy is a hands-on approach that uses various techniques to manipulate the body’s soft tissues. Massage can help relieve muscle tension, reduce stress hormones, and promote relaxation. Regular sessions with a licensed massage therapist can provide both physical and mental benefits, including decreased anxiety levels. Discuss your specific needs and concerns with the therapist to ensure the massage is tailored to your requirements.

Chiropractic Care

Chiropractic care focuses on the musculoskeletal system, particularly the spine, to promote overall health and well-being. While primarily known for its benefits in relieving pain, chiropractic adjustments may also help manage anxiety symptoms. By improving spinal alignment and nerve function, chiropractic care can help reduce physical tension and improve the body’s ability to cope with stress. Consult with a qualified chiropractor to determine if this approach is suitable for you.

Herbal Medicine

Herbal medicine, also known as herbalism, involves using plant-derived substances to support health and treat various ailments, including anxiety. Herbal remedies often combine different plants or plant extracts believed to have calming and anxiety-reducing properties. However, it’s important to note that herbal medicine can have varying degrees of scientific evidence supporting its efficacy and may interact with medications. Consult with a trained herbalist or knowledgeable healthcare provider before incorporating herbal remedies into your anxiety management plan.

What To Pair With Wellbutrin For Anxiety

Seeking Professional Guidance

Consulting a Psychiatrist

Psychiatrists are medical doctors who specialize in the diagnosis and treatment of mental health conditions, including anxiety. If you have severe anxiety symptoms or have not found relief through other approaches, consulting a psychiatrist may be beneficial. Psychiatrists can assess your symptoms, provide a comprehensive evaluation, and recommend appropriate medications or therapies based on your specific needs.

Talking to a Psychologist

Psychologists are mental health professionals who specialize in providing therapy and counseling services. They can help you explore the underlying causes of your anxiety, develop coping strategies, and support you in your journey towards better mental health. Through talk therapy, psychologists can help you gain insight, learn new skills, and develop healthier ways of managing anxiety.

Visiting a Holistic Practitioner

Holistic practitioners take a whole-person approach to health and well-being, considering physical, emotional, and spiritual aspects. They may combine various therapies and techniques to address anxiety symptoms from multiple angles. Holistic approaches may include lifestyle modifications, natural remedies, and energy-based practices. It’s essential to seek out a reputable and qualified holistic practitioner who aligns with your values and provides evidence-based approaches.

Getting a Second Opinion

If you have tried various treatments for anxiety without significant improvement, it may be beneficial to seek a second opinion from another healthcare provider. Another perspective and fresh evaluation may reveal new insights or alternative treatment options that were previously overlooked. Ensure you provide the new healthcare provider with a comprehensive overview of your anxiety symptoms and previous treatment attempts.

Combination Therapies

Wellbutrin + CBT

Combining the medication Wellbutrin with Cognitive Behavioral Therapy (CBT) can be a powerful approach for managing anxiety. Wellbutrin is an antidepressant that can also help reduce anxiety symptoms. When used in conjunction with CBT, which focuses on changing distorted thought patterns and behaviors, this combination can provide a comprehensive approach to anxiety management.

Wellbutrin + SSRI

Another effective combination for anxiety management is pairing Wellbutrin with a Selective Serotonin Reuptake Inhibitor (SSRI). Wellbutrin helps regulate neurotransmitters like norepinephrine and dopamine, while SSRIs increase serotonin levels in the brain. By targeting different neural pathways, this combination may provide a more robust approach to reducing anxiety symptoms.

Wellbutrin + Benzodiazepines

In some cases, a short-term combination of Wellbutrin and a benzodiazepine may be prescribed to manage severe anxiety symptoms. Wellbutrin provides a long-term solution by addressing the underlying causes of anxiety, while benzodiazepines offer immediate relief during periods of intense anxiety. However, it’s important to use benzodiazepines under the close supervision of a healthcare provider due to their potential for dependence and abuse.

Wellbutrin + Lifestyle Changes

Pairing Wellbutrin with lifestyle changes can enhance the overall effectiveness of anxiety management. Incorporating regular exercise, mindfulness practices, and dietary modifications can complement the medication’s effects and promote overall well-being. Lifestyle changes can also provide long-lasting benefits even after discontinuing medication, helping you maintain positive mental health.

Working with a Healthcare Provider

Discussing Concerns and Goals

When working with a healthcare provider to manage anxiety, open and honest communication is essential. Discuss any concerns or questions you may have regarding treatment options, side effects, or potential interactions with other medications. Clarify your goals and expectations, ensuring that both you and your provider are aligned in the direction of your treatment plan.

Understanding Potential Side Effects

Being aware of the potential side effects of medications and other treatment options is crucial for making informed decisions about your anxiety management. Different medications can have varying side effect profiles, and it’s important to understand what to expect and when to seek medical assistance. Your healthcare provider should provide thorough information about potential side effects and guide you on how to manage them.

Monitoring Progress and Adjustments

Regularly monitoring your progress and addressing any adjustments needed is a vital part of anxiety management. Keep track of how you’re feeling, any changes in symptoms, or any troubling side effects. This information will help guide your healthcare provider in making necessary adjustments to your treatment plan. Remember, finding the right combination of therapies and medication may require some trial and error.

Informing about All Medications and Supplements

It’s crucial to inform your healthcare provider about all medications, supplements, or natural remedies you are currently taking or plan to incorporate into your anxiety management plan. Some substances can interact with each other, leading to unwanted side effects or reduced efficacy. Your provider will consider these factors when recommending suitable treatments and monitoring your progress.

Conclusion What To Pair With Wellbutrin For Anxiety

Managing anxiety is a multifaceted journey that often requires a combination of approaches tailored specifically to your needs. Psychotherapy options like Cognitive Behavioral Therapy, Exposure Therapy, Dialectical Behavior Therapy, and Interpersonal Therapy offer valuable tools to address the underlying causes of anxiety and develop healthier coping strategies. Medications like Selective Serotonin Reuptake Inhibitors (SSRIs), Benzodiazepines, Buspirone, and Beta-blockers can provide additional support when necessary.

Incorporating lifestyle changes such as exercise, meditation, dietary modifications, and support groups can contribute to overall well-being and anxiety reduction. Natural supplements like Omega-3 Fatty Acids, Kava, Passionflower, and Valerian Root may offer additional support, but it’s important to consult with your healthcare provider before integrating them into your routine. Stress reduction techniques like deep breathing exercises, progressive muscle relaxation, yoga, and aromatherapy can help calm the mind and promote relaxation.

Alternative therapies, including acupuncture, massage therapy, chiropractic care, and herbal medicine, can provide additional options for anxiety management. Seeking professional guidance from psychiatrists, psychologists, holistic practitioners, or obtaining a second opinion can help ensure you receive comprehensive care. Combination therapies, such as Wellbutrin paired with various approaches, offer a multi-faceted approach to managing anxiety.

Working closely with a healthcare provider, discussing concerns and goals, understanding potential side effects, monitoring progress, and informing about all medications and supplements are essential aspects of effective anxiety management. Remember, everyone’s journey is unique, and it may take time to find the right combination of strategies that work best for you. With patience, persistence, and support, you can significantly reduce anxiety and lead a fulfilling life.

Frequently Asked Questions:

1. Why do I still have anxiety on Wellbutrin? – Individual responses vary. If anxiety persists, consult your healthcare provider to discuss potential adjustments to your treatment plan.

2. How much Wellbutrin should I take for anxiety? – Dosage is personalized based on your specific needs. Your healthcare provider will determine the most suitable amount for anxiety management.

3. Can you take Wellbutrin and Zoloft together for anxiety? – Combining Wellbutrin and Zoloft can be effective for some individuals. Consult your healthcare provider to ensure this combination aligns with your treatment goals.

4. Can you take SSRI and Wellbutrin together? – Combining an SSRI with Wellbutrin is a common approach for managing anxiety and depression. Consult with your healthcare provider for personalized advice.

5. Does bupropion anxiety go away? – Anxiety as a side effect may diminish over time as your body adjusts to bupropion. If concerns persist, consult your healthcare provider.

6. When does Wellbutrin anxiety stop? – Anxiety side effects may alleviate as your body adapts to Wellbutrin. If symptoms persist or worsen, consult your healthcare provider.

7. Is 300mg of Wellbutrin a lot? – Dosage varies among individuals. Your healthcare provider will determine the appropriate dose based on your specific needs and response.

8. Can you take Wellbutrin and Prozac together for anxiety? – Combining Wellbutrin and Prozac may be prescribed in certain cases. Consult your healthcare provider to discuss the potential benefits and risks.

9. What is the best SSRI for anxiety? – The choice of SSRI depends on individual factors. Consult your healthcare provider to determine the most suitable option for managing anxiety.

10. What two antidepressants work well together? – Combinations like Wellbutrin and an SSRI are often prescribed. Your healthcare provider will tailor the combination based on your unique needs.

11. Is Wellbutrin and Lexapro a good combination for anxiety? – Wellbutrin and Lexapro can be a beneficial combination for some individuals. Consult your healthcare provider to discuss the appropriateness for your situation.

12. Why do doctors prescribe Wellbutrin and Prozac together? – Combining Wellbutrin and Prozac may address both depression and anxiety symptoms. Your healthcare provider will determine the best approach for you.

13. Should I take Wellbutrin and sertraline together? – Combining Wellbutrin and sertraline may be appropriate for certain individuals. Consult your healthcare provider to determine the best course of action.

14. What should Wellbutrin not be mixed with? – Wellbutrin may interact with certain medications or substances. Inform your healthcare provider about all medications and supplements you’re taking to avoid potential interactions.

15. Why take Lexapro and Wellbutrin together? – Combining Lexapro and Wellbutrin may provide a more comprehensive approach to address both depression and anxiety symptoms. Consult with your healthcare provider for personalized guidance.

16. Does Wellbutrin cover anxiety? – Wellbutrin is not typically considered a first-line treatment for anxiety, but it may have positive effects on mood. Discuss your symptoms with your healthcare provider for appropriate recommendations.

17. Can you take Xanax and Wellbutrin together? – Combining Xanax and Wellbutrin may be prescribed under careful supervision. Consult your healthcare provider to discuss potential benefits and risks.

18. Does Wellbutrin take away your emotions? – Medication effects vary among individuals. Wellbutrin is generally considered to have a lower risk of emotional blunting compared to some other antidepressants.

19. Will Wellbutrin relax you? – Wellbutrin is not typically known for its sedative effects. It may, however, contribute to improved mood over time. Individual responses vary.

20. Can you drink caffeine on Wellbutrin? – While moderate caffeine consumption is generally considered safe, consult your healthcare provider for personalized advice based on your health status.

21. What is a good combination with Wellbutrin? – Combinations with SSRIs or other antidepressants are common. Your healthcare provider will determine the most suitable combination based on your needs.

22. Who is not a good candidate for Wellbutrin? – Wellbutrin may not be suitable for individuals with certain medical conditions. Consult your healthcare provider to discuss your medical history and determine suitability.

23. Why choose Wellbutrin over other antidepressants? – Wellbutrin is chosen based on individual needs, side effect profiles, and treatment goals. Consult your healthcare provider for personalized recommendations.

24. Does Wellbutrin treat both anxiety and depression? – While Wellbutrin is primarily used for depression, it may also have positive effects on anxiety for some individuals. Discuss your symptoms with your healthcare provider for appropriate guidance.

25. Can I take bupropion with another antidepressant? – Combining bupropion with another antidepressant may be appropriate in certain cases. Consult your healthcare provider for personalized recommendations.

26. Is Wellbutrin the best antidepressant? – The best antidepressant varies among individuals. Wellbutrin may be suitable for some but not others. Consult your healthcare provider to determine the most appropriate option for you.

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